Course Details
Country:
Netherlands
Institution:
Free University of Amsterdam
Course Title:
Induced Pluripotent Stem Cells in Toxicology and Drug Discovery
Course Number:
XB_0095
Course Description:
Studying the effects of pharmaceuticals in human cell culture systems, offers a number of advantages over animal experiments, including the use of human material and the possibility to use mechanistic approaches to understand the mechanism of action or mechanism of toxicity of a compound. In particular the use of iPSC opens exciting new avenues, as they provide unlimited material, are of non-cancerous origin, and can be collected/generated from individual living patients. iPSC can be generated from somatic cells, e.g. from skin fibroblast or blood cells, and in the last decade, many patient-specific iPSC have been made, including cells that carry SNPs or mutations in drug transporters or metabolizing enzymes. These cells can then be differentiated into target cells that are important in toxicology, including cells types of the liver, kidney, heart and intestine, and employed in toxicology studies. Topics addressed in this course include, basic cell culture techniques, iPSC reprogramming
Language:
English
Approved Equivalent:
BIOL 3--
Attachment Files:
Studyguide (21)_1.pdf
